MANAGEMENT GUIDELINES FOR
RASH DUE TO ERBITUX

Sunlight

  • Avoid direct sunlight & wear hats and protective clothing in sunlight
  • Sunscreen (Anti Helios®) use will avoid aggravating the rash by sunlight

Makeup

  • Dermatologist-approved cover-up (e.g. Dermablend®) may be suggested to conceal rash
  • Makeup should be removed with a skin-friendly liquid cleanser (e.g. Neutrogena®, Dove®, or Ivory Skin Cleansing Liqui-Gel® Moisturizer)

Moisturizers

  • Emollients (eg. Neutrogena Norwegian Formula Hand Cream® or Vaseline Intensive Care Advanced Healing Lotion®) can prevent or alleviate skin dryness

Acne medications

  • The use of acne medications (e.g. benzoyl peroxide and retinoids) are not recommended and may further aggravate rash due to their skin drying effects

Topical corticosteroids

  • Current evidence indicates that topical corticosteroids are ineffective

Analgesics

  • Analgesics may be considered before reducing the dose of HER 1 / EGFR-targeted agents

Antihistamines

  • For the rash-associated pruritis, antihistamines may be considered.

Antibiotics

  • If there is a secondary infection.

The effectiveness of agents should be evaluated after one week, and treatment continued for another week. If there is no improvement after 2 weeks, the treatment should be considered ineffective, and discontinued.